Blar i forfatter "Lester, Sue"

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    • Susceptibility for Lupus Nephritis by low copy number of the FCGR3B gene is linked to increased levels of pathogenic autoantibodies 

      Nossent, Johannes C; Becker-Merok, Andrea; Rischmueller, Maureen; Lester, Sue (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (𝑛 = 107). FCGR3B CN was determined by three different qPCR parameter estimations (Ct−, Cy0, and cpD1) and confirmed by the FCGR2C/FCGR2A paralog ratio test. ...